11 Highlighting the importance of this resistance determinant, an increasing trend in qacA prevalence in clinical staphylococcal isolates has been observed in the USA and Asian countries, 7 facilitated by it being a plasmid-borne efflux pump. 8 The 514 amino acid QacA protein belongs to the major facilitator superfamily (MFS) of transport proteins, the largest grouping of secondary active transporters that are present in all classes of living organisms.
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