Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells.

FC-based quantification of endogenous insulin production by GFP reporter fluorescence or intracellular C-peptide staining in sBCs generated from hESCs (Mel1 INSGFP ) or iPSCs, respectively, revealed a highly significant increase in sBCs in Bleo-treated clusters compared with Veh-treated clusters ( Figure 3 A).

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