Barely Significant
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Prognostic and predictive significance of circulating biomarkers in patients with advanced upper gastrointestinal cancer undergoing systemic chemotherapy.

Front Oncol · 2023 · PMC10280739 · PMID 37346066

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a decreasing trendno p-value reported
According to a previous report, the loss of CD28 expression on T cells was significantly associated with the aging of the immune system ( 30 ); this report identified a decreasing trend of CD8 + CD28 + T cells with age.

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