Dendritic cell-intrinsic LKB1-AMPK/SIK signaling controls metabolic homeostasis by limiting the hepatic Th17 response during obesity.

Although significant differences in glucose levels were already present at baseline, complexifying the interpretation of the data, similar results were obtained during an insulin tolerance test (ITT) ( Figure 2I ), with a borderline significant ( P = 0.08) lower glucose drop in the acute response to insulin bolus in CD11c ΔLKB1 compared with CD11c WT mice ( Figure 2J ).

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