Association of Self-reported Systemic Reactions Following SARS-CoV-2 Vaccination With Immunological Response in the Danish National Cohort Study of Effectiveness and Safety of SARS-CoV-2 Vaccines (ENFORCE).

However, following the second vaccination, the association in the primary analysis was highly significant (global P < .001), with participants who scored 2 or more (at least 2 moderate or 1 severe reaction) having significantly higher post–vaccination spike IgG levels than those who had a score of 0; adjusted geometric mean ratios were 1.16 (95% CI, 1.04–1.30), 1.24 (95% CI, 1.09–1.41), 1.25 (95% CI, 1.06–1.46), and 1.21 (95% CI, 1.08–1.35), for scores of 2, 3, 4, and ≥5, respectively.

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