Bio-psycho-social factors' associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants.

Linear mixed effect models explaining brain age gap from bio-psycho-social factors We ran the proposed five baseline and bio-psycho-social models with the first principal component (PC) of the numeric predictors from each of the models showing a small proportion of the variance in brain age uniquely explained by the principal components ( R 2 < 1%; Supplementary Table S5 ), with differences between these models and respective baseline models yet being highly significant ( Supplementary Table S6 ).

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