<i>New anti-diabetic drug Morus alba L.</i> (Sangzhi) alkaloids (SZ-A) improves diabetic nephropathy through ameliorating inflammation and fibrosis in diabetic rats.

Front Med (Lausanne) · 2023 · PMC10289017 · PMID 37359004

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an increasing trendp > 0.05actually significant

SZ-A relieves renal injury by decreasing systemic nitrosative stress in diabetic ZDF rats In comparison with Con, repeated treatments with SZ-A significantly decreased the blood iNOS and NO levels in diabetic ZDF rats ( p < 0.05, Figures 4A , B ), and showed an increasing trend of blood T-AOC and SOD levels ( p > 0.05, Figures 4C , D ).

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a decreasing trendno p-value reported

In the present study, SZ-A treatment showed no significant effects on the oxidative stress-related enzymes, such as T-AOC, SOD1, CAT, GPX1, NOX1, or NOX4, but significantly decreased the blood iNOS and NO levels, although it only showed a decreasing trend of renal iNOS expression.

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