Homocysteine induces ferroptosis in endothelial cells through the systemXc^-/GPX4 signaling pathway.

2.2 .A&B), and the tendency of lipid peroxidation was more significant with the increase of HCY concentration (** p < 0.05); while the Lip-ROS content gradually decreased in the cells co-cultured with Fer-1, showing a decreasing trend (** p < 0.05) (Fig. 2.2 .A&C).

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