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Cryo-EM Structures of the Klebsiella pneumoniae AcrB Multidrug Efflux Pump.

mBio · 2023 · PMC10294659 · PMID 37067435

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an increasing trendno p-value reported
There is also an increasing trend of resistance to carbapenems, tigecycline and even the last resort drug colistin ( 39 , 40 ) that severely limits the choice of therapies.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.