Exploring the Potential Role of ADAM 17 and ADAM 22 in the Etiology of Autism Spectrum Disorders.

Brain Sci · 2023 · PMC10296508 · PMID 37371450

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It may help to highlight the importance of glutamate excitotoxicity and neuroinflammation as two key contributors to the etiology of ASD given the strong negative correlation between plasma ADAM 22 and CARS as a measure of ASD severity as well as the highly significant positive correlations between ADAM17 as protein connected to inflammation and ADAM22 as marker directly associated with glutamate neurotoxicity.

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