Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights.

Cells · 2023 · PMC10297078 · PMID 37371116

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highly significantno p-value reported

Mutant-Tau-expressed and Rlip-RNA-silenced cells showed highly significant toxicity to the hippocampal neurons in almost all parameters investigated in the current study—cell survival, mitochondrial respiration, synaptic and mitophagy defects, and mitochondrial damage and mitochondrial function.

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