In addition, in a 12-week prospective, randomized, double-blind controlled trial of 37 patients with apathy, the authors showed that postoperative apathy and depression responded to piribedil, a D2/D3 dopamine agonist, while a trend toward significance was noticed for anhedonia [ 100 ].
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Apathy in Parkinson's Disease: Clinical Patterns and Neurobiological Basis.
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