Adenosine A_2A Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages.

Interestingly, the activation of RAW 264.7 and IPMФ cells with LPS induced an increasing trend, although not significant, in the number of specific spots for the NPC1 protein, the relative intensity of the spot, the total area of the spot, and the number of spots per area in both the plasma membrane and cytoplasmic regions of the cells compared to untreated cells ( Figure 4 B and Figure 5 B and Figure S1A,B ).

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