Through analysis of RNA-seq data of PANC-1-IN cells after GATM knockdown, we observed a decreasing trend in HMT expressions and an increasing trend in histone demethylase (HDM) expressions (Fig. 7 B).
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Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications.
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We found an increasing trend in the bioluminescence signal in mice in the GAA diet group compared to the control group (Fig. 2 D).