Involvement of the Opioidergic Mechanism in the Analgesic Potential of a Novel Indazolone Derivative: Efficacy in the Management of Pain, Neuropathy, and Inflammation Using <i>In Vivo</i> and <i>In Silico</i> Approaches.

Gabapentin (GP) 75 mg kg –1 showed a highly significant response, viz., [*** p < 0.001 (30 min), *** p < 0.001 (60 min), ** p = 0.001 (90 min)], in comparison to the vincristine-treated animals.

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The test compound ID demonstrated [** p = 0.004 (30 min), ** p = 0.004 (60 min), ** p = 0.009 (90 min)] at 40 mg kg –1 and [*** p < 0.001 (30–90 min)] at 60 mg kg –1 compared to the vincristine-treated group (VINC). GP also showed an increasing trend in the paw withdrawal threshold of the vincristine-induced neuropathic mice to the applied force (s) as compared to the normal control animals when tested with von Frey filaments ( Figure 10 ).

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