Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol.

Cardiovasc Res · 2023 · PMC10318398 · PMID 36718802

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Interestingly, mainly DEGs in CXCL14+ trajectory showed a highly significant enrichment and the involved DEGs could be linked to the GO terms of this trajectory, e.g. lipid metabolism and inflammation. 3 , 35 Thus, we studied if changes in the environment, such as in CVD, differentially affected the most differentiated fibroblast clusters in each trajectory.

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