CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.

Similarly, the association between N-oleoyl-leucine and future heart failure remained highly significant when further adjusted for free leucine (HR 0.78; 95% CI, 0.66–0.91; p -value = 2.1 × 10 −3 ; median follow-up 12.6 years).

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