MR1 deficiency enhances IL-17-mediated allergic contact dermatitis.

To examine CD4 + T cells in DNFB-challenged pinnae, we analyzed the cells obtained on day 2 of elicitation, and a similar frequency was observed for WT and MR1 -/- mice, although an increasing trend in the number of Th cells was observed in MR1 -/- mice compared to WT mice ( Figure 6E ).

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When T-bet + cells (Th1) were analyzed among CD4 + CD3 + cells, the frequency of T-bet + cells in the dLNs of MR -/- mice was lower than that in WT mice, and the number of T-bet + CD4 + T cells also exhibited a decreasing trend ( Figure 5B ).

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