The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes.

Front Physiol · 2023 · PMC10319582 · PMID 37415908

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Measurements of blood cytokines in LPS-exposed dams at 24 h demonstrated systemic inflammation with highly significant elevations in IL-1β, IL-6, KC, MCP-1 ( Figure 2B ) and eNAMPT levels ( Figure 2D ) when compared to unexposed dams.

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