Should Patients with Renal Cell Carcinoma and Pathological Nodal Invasion Be Classified As Having Stage IV Disease?

9 As the third most common genitourinary tract malignancy, approximately 403,262 RCC cases were newly diagnosed globally, with 175,098 deaths in 2018, 10 and incidence exhibiting an increasing trend as well. 11 With rapid eruption of systemic treatment in the recent decade, continuous monitoring and revision of the staging system is mandatory to provide most updated treatment guidance and risk stratification accordingly. 12 Currently, there is only one study advocating that LN invasion should

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