We observed a significant increase in synaptic cCas-3 intensity (red-boxed region) and an increasing trend of cell body cCas-3 intensity (yellow-boxed region) in the Sord-deficient flies, indicating increased motor neuron apoptosis.
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Sorbitol reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration in sorbitol dehydrogenase deficiency.
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