Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1.

Nat Microbiol · 2023 · PMC10322710 · PMID 37169919

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highly significantno p-value reported

This revealed a highly significant impact of the S258 L mutation, which increased CQ IC 50 values 1.5-fold, and a more moderate but significant impact of F313 S and the double mutation (S258 L /F313 S ), relative to the ancestral (258S/313F) allele (Fig. 5b ).

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