Snakes and Ladders: A Potential Therapy of Hepatocyte Growth Factor and Pigment Epithelium-derived Factor in Pulmonary Hypertension.

This finding provides an important mechanistic link between PEDF and its beneficial physiological effects in PH and identifies these complexes as novel targets for disease therapy that can be exploited to limit vascular leakage in diseases such as acute respiratory distress syndrome, in which loss of barrier function is highly significant and focal adhesion proteins play an important therapeutic role ( 22 ).

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