IL-7 producing immunotherapy improves <i>ex vivo</i> T cell functions of immunosenescent patients, especially post hip fracture.

hIL-7-Fc produced by the MVA-IL-7-Fc induces activation of IL-7 intracellular signaling As IL-7 activity in T-cells is driven mainly by STAT5 phosphorylation and to a lesser extent by STAT1 phosphorylation, proportions of phospho-STAT5 (pSTAT5), and phospho-STAT1 (pSTAT1) were assessed among CD8 T cells and CD4 T cells ( Figure 2 and S4). While pSTAT5 was not induced when T cells were left unstimulated or were stimulated with empty MVA supernatant, MVA-hIL7-Fc supernatant-treated CD8 and CD4 T cells displayed a highly significant pSTAT5 induction in both HF patient and old control groups ( Figure 2a ).

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