Risk factors for the development of premature ventricular complex-induced cardiomyopathy: a systematic review and meta-analysis.

Dose–response analysis of PVC burden In the dose–response analysis encompassing 7 studies reporting PVC burden at different cutoffs, there was a highly significant association between increase in PVC burden and an exponential increase in risk for PVC-CM (at 10% PVC burden, beta-coefficient 1.54 [1.3, 1.8], at 20% PVC burden beta-coefficient 1.5 [1.7, 3.6], at 30% PVC burden beta-coefficient 4 [2.3, 7], Fig. 10 ).

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