Single fibre cytoarchitecture in ventilator-induced diaphragm dysfunction (VIDD) assessed by quantitative morphometry second harmonic generation imaging: Positive effects of BGP-15 chaperone co-inducer and VBP-15 dissociative corticosteroid treatment.

Statistical results were considered significant at the p = 0.05 level and are expressed as *: p < 0.05 for significant, p < 0.001 for highly significant and ‘n.s.’ for not significant. 3 Results 3.1 Quantitative SHG morphometry tracks single fibre atrophy and myofibrillar disorder in diaphragm during ongoing ICU condition and pharmacological intervention As detailed in the Methods section, we applied Second Harmonic Generation (SHG) imaging followed by quantitative morphometry to single muscle fibres from diaphragms of rats subjected to a 10-day ICU-intervention involving controlled mechanical ventilation (MV) and neuromuscular blockade (NMBA) ( Figure 1A ).

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