Many high impact papers have been published on the effect of SMARC genes, and in particular SMARCA4 , 11 , 12 , 13 on patient response to immunotherapy treatment, with some suggesting a positive trend and others providing evidence of inducing drug resistance when co-mutated with STK11 or KEAP1 .
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Mutational landscape of SWI/SNF complex genes reveal correlation to predictive biomarkers for immunotherapy sensitivity in lung adenocarcinoma patients.
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