Expression of the endocannabinoid system and response to cannabinoid components by the human fetal testis.

The pairwise comparisons versus the control condition evidenced a significant decrease starting at 10 −6 M in the 10–12 DW testes, with an even more pronounced impact at 10 −5 M ( p = 0.0005), as well as a highly significant decrease at 10 −5 M in 8 – 10 DW testes ( p = 0.0004) for the CBD/THC mix (Fig. 5 C).

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A massive increase in the density of cleaved caspase 3-positive apoptotic cells was obvious in fetal testis explants exposed to CBD/THC at 10 −5 M, while the increase cell apoptosis induced by CBD at 10 −5 M was borderline significant (Fig. 8 B).

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