Naturally mutagenic sequence diversity in a human type II topoisomerase.

The community structure for an hTOP2β•ATP•DNA ternary complex revealed an interesting trend in which etoposide-sensitizing mutations—which were found to frequently make topoisomerase II more innately cleavage-prone—also tended to reside at the interfaces between motion-coupled communities ( Fig. 4 and SI Appendix , Fig.

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