A PAM of the α<sub>1A</sub>-Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer's disease mouse models without effects on blood pressure.

Curr Res Pharmacol Drug Discov · 2023 · PMC10336260 · PMID 37448695

Europe PMC DOI

hedged sentences

0.1200

closest p · 2.4× alpha

0.1200

boldest claim

The sentences

near significancep < 0.12not close (p > 0.1)

However, Cmpd-3 at 9 mg/kg dose was trending near significance at reducing Nf-l levels (p < 0.12 ) and may be able to become significant if more animals are used.

also in 151 other papers

highly significantno p-value reported

2 ) produced highly significant results on LTP which suggests that long-term dosing is safe and effective.

also in 33,666 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.