highly significantp = 1.5 × 10 −14
Acquisitions of 14.5 min duration performed on anesthetized, spontaneously respiring animals, without gating and administration of contrast agent resulted in a highly significant correlation (R = 0.98, p = 1.5 × 10 −14 ) between the MRI-derived liver volumes and the post-mortem liver weights in hepatectomized, untreated mice. 1,4-bis [2-(3, 5-dichloropyridyloxy)] benzene (TCPOBOP), a synthetic agonist of the mouse constitutive androstane receptor and a potent activator of cytochrome P450 monooxygenase activity ( Halwachs et al., 2007 ) shown earlier to induce hepatocyte proliferation and hepatomegaly ( Ledda-Columbano et al., 2000 ), was then evaluated as test compound in the model.