Amyloid beta-correlated plasma metabolite dysregulation in Alzheimer's disease: an untargeted metabolism exploration using high-resolution mass spectrometry toward future clinical diagnosis.

Conversely, in plasma samples, while uric acid displayed a decreasing trend, both creatine and choline indicated no significant differences between the two groups (Zhang et al., 2022 ).

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However, another study revealed a significant decrease in plasma levels of total tau among individuals with MCI compared with cognitively normal controls, with a further highly significant reduction in AD patients compared with both MCI and normal controls (Sparks et al., 2012 ).

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