How acute myeloid leukemia (AML) escapes from FMS-related tyrosine kinase 3 (FLT3) inhibitors? Still an overrated complication?

Cancer Drug Resist · 2023 · PMC10344728 · PMID 37457126

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a statistical trendno p-value reported

However, a retrospective analysis in 260 patients with AML FLT3-ITD positive, which divided FLT3-ITD into 3 groups based on its position, was unable to confirm this finding, and just showed a statistical trend towards a link between a more C-terminal location of FLT3-ITD and worse survival, but without impacting on EFS [ 79 ] .

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