Effects of Daily Zinc Alone or in Combination with Other Nutrient Supplements on the Risk of Malaria Parasitaemia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

However, the analysis demonstrated a borderline significant effect of zinc supplementation in combination with other micronutrients on the risk of malaria parasitaemia compared with placebo ( p = 0.05, log RR = 1.31, 95% CI: 0.03–2.59, I 2 = 99.22%, with 8904 malaria cases in the zinc intake group and 522 malaria cases in the placebo group).

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The borderline significance and the presence of substantial heterogeneity in the overall analysis indicate the need for further investigation and consideration of additional factors.

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