Formulation and Evaluation of PLGA Nanoparticulate-Based Microneedle System for Potential Treatment of Neurological Diseases.

Int J Nanomedicine · 2023 · PMC10348379 · PMID 37457799

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an increasing trendno p-value reported

32 As shown in Figure 4A , the fluorescent intensity of the Rh-NPs-DMNs group showed an increasing trend from 1.81×10 15 [p/s/cm 2 /sr]/[μW/cm 2 ] to 2.48×10 15 [p/s/cm 2 /sr]/[μW/cm 2 ] during 0–3 h, which was due to the embedded skin needle tip layer in the tissue fluid gradual dissolution and diffusion under the action of the micro-needle patch with the simultaneous release of drug at this stage.

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