Emergence of nociceptive functionality and opioid signaling in human induced pluripotent stem cell-derived sensory neurons.

Pain · 2023 · PMC10348637 · PMID 36727909

Europe PMC DOI

hedged sentences

0.0506

closest p · 1.0× alpha

0.0506

boldest claim

The sentences

almost significantP = 0.0506so close (0.05 < p ≤ 0.1)

The DOP agonist Deltorphin II, on the contrary, showed an almost significant reduction of the PKA-II activity at 20 μM ( P = 0.0506), but not at 10 μM (Fig. 6 E).

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a slight trendno p-value reported

By contrast, stimulation of hiPSCdNs with the GPCR ligands, serotonin (5-HT), and cicaprost (Cic, more stable prostacyclin PGI2 analogue) resulted in no significant pRII responses, although a slight trend towards increased responses was detectable after longer maturation times (Figs. 5 C and D).

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