The <i>Plasmodium falciparum</i> exported J domain proteins fine-tune human and malarial Hsp70s: pathological exploitation of proteostasis machinery.

These studies are highly significant, since PFE0055c is essential to the survival of the malaria parasite, and because PFE0055c, PFA0660w and PfHsp70-x associate in J dots ( Külzer et al., 2010 ; Külzer et al., 2012 ; Petersen et al., 2016 ) which are implicated in the trafficking of key virulence factors ( Külzer et al., 2012 ; Behl et al., 2019 ), making them potential anti-malarial drug targets ( Daniyan and Blatch, 2017 ; Dutta et al., 2021a ; Almaazmi et al., 2022 ; Blatch, 2022 ).

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