Diacerein ameliorates cholestasis-induced liver fibrosis in rat via modulating HMGB1/RAGE/NF-κB/JNK pathway and endoplasmic reticulum stress.

Sci Rep · 2023 · PMC10349817 · PMID 37454204

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Furthermore, the immunohistochemical analysis of CHOP showed a highly significant (p < 0.001) increase in the expression of this protein in the liver samples of the BDL group (37.5% moderate , 62.5% strong ) as compared to the sham-operated rats.

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