Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits <i>Acinetobacter</i>-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum.

For the larger cephalosporins (ceftazidime, cefiderocol, and ceftolozane), there was a notable trend for the Adup variants to have higher k cat / K M values than ADC-7, -30, and -162 ( Figure 8 A).

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A radar plot of the k cat / K M values ( Figure 8 A) shows an overall trend of higher catalytic efficiency by the Adup variants, with the highest activity by ADC-33.

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