APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading.

J Clin Invest · 2023 · PMC10351966 · PMID 37279069

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a nonsignificant trendno p-value reported

We also observed a nonsignificant trend toward increased NP-tau seeding and spreading in the hippocampus of sleep-deprived APPPS1:E4, but not APPPS1:E3, mice ( Figure 4, G and H ).

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