Mid-life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants.

Additionally, the hazard ratios (HR) comparing each longer TL group to the short TL group showed a decreasing trend: HR = 0.78 (95% CI 0.68–0.90, p = 7.2 × 10 −4 ) for moderately short versus short, HR = 0.61 (95% CI 0.53–0.70, p < 2.2 × 10 −16 ) for slightly short versus short, HR = 0.46 (95% CI 0.40–0.52, p < 2.2 × 10 −16 ) for slightly long versus short, HR = 0.36 (95% CI 0.31–0.42, p < 2.2 × 10 −16 ) for moderately long versus short, and HR = 0.26 (95% CI 0.20–0.35, p < 2.2 × 10 −16 ) for long versus short.

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