Nontargeted Metabolomics Revealed Novel Association Between Serum Metabolites and Incident Acute Coronary Syndrome: A Mendelian Randomization Study.

In 1‐sample MR analysis within the DFTJ cohort, we did not observe any causal association of aspartylphenylalanine with incident ACS (OR [95% CI], 0.92 [0.69–1.22]; P =0.554; Table 3 ), but in 2‐sample MR analysis, we found that aspartylphenylalanine level was significantly causally associated with higher SBP (β [95% CI], 0.08 [0.01–0.15]; P =0.024; Table S11 ) and hypertension risk (β [95% CI], 1.04 [1.02–1.06]; P =0.001; Table S11 ), and with higher serum triglyceride level with a marginal significance (β [95% CI], 0.16 [−0.02 to 0.34]; P =0.077; Table S11 ), whereas pleiotropy assessment was not applicable as only 2 genetic instruments were used (Tables S11 and S12 ).

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