A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Nat Commun · 2023 · PMC10356841 · PMID 37468498

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantp ≤ 1e-06actually significant

In Supplementary Data 6 , the association of CHRM3 activation with “urinary contraction” (literature ID 364) contains the p value and ROC AUC for “Urinary retention” and is classified as highly significant ( p ≤ 1e-06), with distance 1 (i.e., the significant PT and starting PT are connected via 1 intermediate in the network, via the shared HT).

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likely to be significantp < 0.001actually significant

However, 128 associations flagged by the model as unlikely to be significant have strong support from our data ( p < 0.001).

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marginally significantp value ~0.07so close (0.05 < p ≤ 0.1)

As such, 12 to 72 tests (median of 12) were conducted per literature association, and we classified as “marginally significant” those associations with KW p value between 0.05 and 0.001 (nominal p value of 0.001 with 72 tests yields a Bonferroni-corrected p value ~0.07).

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