Responsiveness to endurance training can be partly explained by the number of favorable single nucleotide polymorphisms an individual possesses.

PLoS One · 2023 · PMC10358902 · PMID 37471354

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highly significantno p-value reported

In this connection, a study [ 71 ] investigating the role of NOTCH1 mutations in Aortic Stenosis (AS), found a highly significant association of rs2229974 with AS, which will likely have an impact on an individual’s exercise performance ability.

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