On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase.

Nucleic Acids Res · 2023 · PMC10359454 · PMID 37246710

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highly significantno p-value reported

The direct comparison of the mutant and WT methylation rates at all 256 sites revealed a highly significant ( P -value 8.66 × 10 −67 , based on two-sided t-test of paired data) but mild about 2.5-fold reduced HM/UM specificity of the CXXC mutant (Figure 4A ).

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