Analgesic effect of oral paracetamol 1000 mg/ibuprofen 400 mg, paracetamol 1000 mg/codeine 60 mg, paracetamol 1000 mg/ibuprofen 400 mg/codeine 60 mg, or placebo on acute postoperative pain: a single-dose, randomized, and double-blind study.

However, an interesting numerical difference supported by a statistical trend was found between sexes in the codeine containing paracetamol 1000 mg/codeine 60 mg ( p = 0.10) and ibuprofen 400 mg/paracetamol 1000 mg/codeine 60 mg ( p = 0.14) groups where females score numerically higher SPI than males (Table 1 ).

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