Alzheimer's disease-associated complement gene variants influence plasma complement protein levels.

J Neuroinflammation · 2023 · PMC10362776 · PMID 37480051

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highly significantno p-value reported

The causative association between these SNPs and changes in plasma sCR1 levels was tested using endophenotype GWAS; the rs6656401-tagged LD block associated with expression of CR1*2 was highly significant in the analysis, confirming its direct effect on plasma sCR1 levels; in contrast, the rs6691117 SNP did not reach GWS for association with plasma sCR1 changes.

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