found that norvaline and myristic acid showed an increasing trend, and 20 CRC-enriched metabolites distinguished CRC from CRA and healthy control; further integration of microbial metagenomic data showed that the ability to distinguish CRC from CRA and healthy control was improved with AUC of 0.94 and 0.92 respectively. 44 Moreover, a few studies from China tried to find the gut microbial biomarkers for early-onset CRC. 27 , 28 , 94 One study showed that multi-omics signatures of early-onset CRC might be associated with enriched F. plauti and increased tryptophan, BAs, and choline metabolism.
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