Abandoning Caprini Scores and Chemoprophylaxis ("Bloodletting 2.0"): A Call for Action.

41 , 42 If these studies had been included, there would be a highly significant ( P < 0.00001) association between chemoprophylaxis and postoperative bleeding. 38 Moreover, a 2016 meta-analysis by Pannucci et al 43 found a higher risk of hematomas ( P = 0.02) in anticoagulated plastic surgery patients, in addition to no significant reduction in VTE risk in plastic surgery inpatients with Caprini scores >8.

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3 A marginally significant overall benefit for postoperative enoxaparin administration ( P = 0.042) 14 was determined only after applying questionable statistical adjustments to the data analysis. 3 , 17 , 24 It is remarkable that the raw data showed identical VTE rates in the 2 large patient groups, but the authors concluded that there was a significant benefit from anticoagulation, a testament to the authors' motivation to find a significant difference.

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