Dexmedetomidine Improves Anxiety-like Behaviors in Sleep-Deprived Mice by Inhibiting the p38/MSK1/NFκB Pathway and Reducing Inflammation and Oxidative Stress.

Brain Sci · 2023 · PMC10377202 · PMID 37508990

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highly significantp < 0.05actually significant

The expression levels of oxidative stress-related factors (iNOS [F = 9.649] and COX-2 [F = 6.804]) were significantly higher in the SD group than in the CC group ( p < 0.01) and lower in the SD + Dex group than in the SD + saline group ( p < 0.05), with the difference in iNOS levels being highly significant ( p < 0.05).

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